Biological Activities of Polygonum aviculare Ethanol Extract
DOI:
https://doi.org/10.1071/ejmbs.v5i2.43Keywords:
Antioxidant activity, cholinesterase inhibition, antiproliferative effect, natural products, phytotherapyAbstract
Polygonum aviculare (P. aviculare) exhibits diverse biological activities thanks to its rich phenolic compounds and flavonoids. In this study, the antioxidant, anticholinesterase, and antiproliferative activities of P. aviculare were evaluated using ethanol extract. Plant material was prepared by Soxhlet extraction, and total antioxidant capacity (TAS), total oxidant level (TOS), and oxidative stress index (OSI) were measured using commercial Rel Assay kits. TAS value was found to be 5.436±0.097 mmol/L, TOS value was 10.830±0.103 µmol/L, and OSI value was 0.199±0.005, indicating that the extract has a strong antioxidant capacity. Anticholinesterase activity was assessed using the Ellman method, and IC₅₀ values were determined as 85.773±3.551 µg/mL for AChE and 117.933±3.192 µg/mL for BChE. Although weaker activity was observed compared to the reference inhibitor galantamine, it was found to be a noteworthy natural inhibitor source. Furthermore, antiproliferative activity was investigated in the A549 lung cancer cell line using the MTT assay, and it was determined that the extract significantly reduced cell viability, especially at concentrations of 100 and 200 µg/mL. The findings demonstrate the multifaceted biological activities of P. aviculare and support its evaluation as a potential bioresource in natural therapeutic approaches.
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