Investigation of the antifungal activities of cryogels for potential use as wound dressing materials
Antifungal activities of Cryogels
DOI:
https://doi.org/10.1071/ejmbs.v3i1.32Anahtar Kelimeler:
Cryogels- fungemia- anti-fungal activity- Saccharomyces cerevisiaeÖzet
The fungus can act as a pathogen and disrupt the immune system. Therefore, materials with antifungal properties can provide an essential deterrent against fungal infections. The eukaryotic yeast cell model Saccharomyces cerevisiae, known as baker’s yeast , is widely used in food industry in baking, winemaking, and brewing. Moreover it is also commonly used as a probiotic for treating gastroenteritis and regulating the endogenous flora and immune system. However, in recent years, there has been an increase in cases of fungemia caused by S. cerevisiae and its subspecies, S. boulardii, and and therefore caution should be exercised when using it as probiotic especially in immunocompromised individuals or low weight infants. Cryo-hydrogels, called cryogels, are mainly used in biotechnological fields due to their fast mass flow properties supported by the elastic morphological structures combined with mechanical and chemical stability. Also, these polymers are a valuable option for wound-healing materials. In this study, HEMA-based cryogels containing different amounts of N-Vinylformamide were prepared and characterized to investigate their anti-fungal activities on Saccharomyces cerevisiae. The results indicated that, PHEMA/PNVF cryogels showed considerable effectiveness against this opportunistic strain. So, PHEMA/PNVF can be considered a potential wound dressing material for future studies
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