The Effects of Symptomatic Bacterial Vaginosis in the Second Trimester of Pregnancy on Pregnancy Outcome
Bacterial Vaginosis and Pregnancy Outcome
DOI:
https://doi.org/10.1071/ejmbs.v5i1.57Keywords:
Bacterial vaginosis, premature rupture, preterm delivery, second trimesterAbstract
A prospective cohort study was designed to evaluate the correlation between the presence of bacterial vaginosis and pregnancy outcomes. 192 pregnant women in the second trimester of pregnancy with vaginal discharge were included in the study.The study group consisted of 50 pregnant women positive for the presence of bacterial vaginosis. 138 pregnant women without bacterial vaginosis constituted the control group and both groups were compared in respect to the pregnancy outcomes. Neither the timing of the delivery nor the presence of chorioamnionitis, wound infections or postpartum endometritis showed a statistically significant difference between the groups (p > 0.05). The incidences of both preterm labor and premature rupture of membranes were found to be significantly higher in the group of patients with bacterial vaginosis (p <0.05). The presence of bacterial vaginosis in the second trimester of pregnancy increases the rates of premature rupture of membranes as well as preterm labor. Other complications of pregnancy exhibited a somewhat similar increase in number however these figures were statistically insufficient to prove a significant correlation inbetween. We suppose that a new study group of a substantially larger scale will demonstrate a significant increase in these complications as well.
References
Bhakta, V., Aslam, S., Aljaghwani, A. (2021). Bacterial vaginosis in pregnancy: prevalence and outcomes in a tertiary care hospital. African journal of reproductive health, 25(1), 49-55.
Bothuyne-Queste, E., Hannebicque-Montaigne, K., Canis, F., Noulard, M. N., Plennevaux, J. L., Tilloy, E., Subtil, D. (2012). Is the bacterial vaginosis risk factor of prematurity? Study of a cohort of 1336 patients in the hospital of Arras. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction, 41(3), 262-270.
Brocklehurst, P., Gordon, A., Heatley, E., Milan, S. J. (2013). Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database of Systematic Reviews, (1), CD000262
Flynn, C. A., Helwig, A. L., & Meurer, L. N. (1999). Bacterial vaginosis in pregnancy and the risk of prematurity. J Fam Pract, 48(11), 885-892.
Guerra, B., Ghi, T., Quarta, S., Morselli-Labate, A. M., Lazzarotto, T., Pilu, G., & Rizzo, N. (2006). Pregnancy outcome after early detection of bacterial vaginosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 128(1-2), 40-45.
Hoffmann, E., Vancsa, S., Varadi, A., Hegyi, P., Nagy, R., Hamar, B., Futács, V., Kepkep, B., Nyirády, P., Demendi, C., Acs, N. (2023). Routine screening of abnormal vaginal flora during pregnancy reduces the odds of preterm birth: a systematic review and meta-analysis. Scientific Reports, 13(1), 13897.
Jacobsson, B., Pernevi, P., Chidekel, L., & JörgenPlatz-Christensen, J. (2002). Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis. Acta obstetricia et gynecologica Scandinavica, 81(11), 1006-1010.
Klebanoff, M. A., Schuit, E., Lamont, R. F., Larsson, P. G., Odendaal, H. J., Ugwumadu, A., Kiss, H., Petricevic, L., Andrews, W.W., Hoffman, M.K., Shennan, A., Seed, P.T., Goldenberg, R.L., Emel, L.M., Bhandaru, V., Weiner, S., Larsen, M. D. (2023). Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: systematic review and individual participant data meta‐analysis. Paediatric and perinatal epidemiology, 37(3), 239-251.
Leitich, H., Bodner-Adler, B., Brunbauer, M., Kaider, A., Egarter, C., Husslein, P. (2003). Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. American journal of obstetrics and gynecology, 189(1), 139-147.
Martius, J., Eschenbach, D. A. (1990). The role of bacterial vaginosis as a cause of amniotic fluid infection, chorioamnionitis and prematurity--a review. Archives of gynecology and obstetrics, 247(1), 1-13.
McGregor, J. A. (2000). Bacterial vaginosis in pregnancy. Obstetrical & Gynecological Survey, 55(5), 1-19.
Menard, J. P., & Bretelle, F. (2012). Bacterial vaginosis and preterm delivery. Gynécologie, obstétrique & fertilité, 40(1), 48-54.
Mu, Y., Hu, A., Kan, H., Li, Y., He, Y., Fan, W., Liu, H., Li, Q., Zheng, Y. (2023). Preterm Prelabor rupture of membranes linked to vaginal Bacteriome of pregnant females in the early second trimester: a case-cohort design. Reproductive Sciences, 30(7), 2324-2335.
Ng, B. K., Chuah, J. N., Cheah, F. C., Mohamed Ismail, N. A., Tan, G. C., Wong, K. K., Lim, P. S. (2023). Maternal and fetal outcomes of pregnant women with bacterial vaginosis. Frontiers in surgery, 10, 1084867.
Nugent, R. P., Krohn, M. A., Hillier, S. L. (1991). Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. Journal of clinical microbiology, 29(2), 297-301.
Nygren, P., Fu, R., Freeman, M., Bougatsos, C., Klebanoff, M., Guise, J. M. (2008). Evidence on the benefits and harms of screening and treating pregnant women who are asymptomatic for bacterial vaginosis: an update review for the US Preventive Services Task Force. Annals of internal medicine, 148(3), 220-233.
Oakeshott, P., Kerry, S., Hay, S., Hay, P. (2004). Bacterial vaginosis and preterm birth: a prospective community-based cohort study. The British Journal of General Practice, 54(499), 119.
Obata-Yasuoka, M., Ba-Thein, W., Hamada, H., Hayashi, H. (2002). A multiplex polymerase chain reaction-based diagnostic method for bacterial vaginosis. Obstetrics & Gynecology, 100(4), 759-764.
Oliver, R. S., Lamont, R. F. (2013). Infection and antibiotics in the aetiology, prediction and prevention of preterm birth. Journal of Obstetrics and Gynaecology, 33(8), 768-775.
Riduan, J. M., Hillier, S. L., Utomo, B., Wiknjosastro, G., Linnan, M., Kandun, N. (1993). Bacterial vaginosis and prematurity in Indonesia: association in early and late pregnancy. American journal of obstetrics and gynecology, 169(1), 175-178.
Sethi, N., Narayanan, V., Saaid, R., Ahmad Adlan, A. S., Ngoi, S. T., Teh, C. S. J., Hamidi. M., WHOW research group Tan Kim Kee Zuraiju Siti Nur Edlyn Nadia Razali Asbah Ong Siew Kian Ng Doris Sin Wen Syed Jafer Hussain Zaidi Syeda Nureena. (2025). Prevalence, risk factors, and adverse outcomes of bacterial vaginosis among pregnant women: a systematic review. BMC pregnancy and childbirth, 25(1), 40.
Sha, B. E., Chen, H. Y., Wang, Q. J., Zariffard, M. R., Cohen, M. H., Spear, G. T. (2005). Utility of Amsel criteria, Nugent score, and quantitative PCR for Gardnerella vaginalis, Mycoplasma hominis, and Lactobacillus spp. for diagnosis of bacterial vaginosis in human immunodeficiency virus-infected women. Journal of clinical microbiology, 43(9), 4607-4612.
Svare, J. A., Schmidt, H., Hansen, B. B., Lose, G. (2006). Bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. BJOG: An International Journal of Obstetrics & Gynaecology, 113(12), 1419-1425.
Tam, M. T., Yungbluth, M., & Myles, T. (1998). Gram stain method shows better sensitivity than clinical criteria for detection of bacterial vaginosis in surveillance of pregnant, low‐income women in a clinical setting. Infectious diseases in obstetrics and gynecology, 6(5), 204-208.
Thorsen, P., Vogel, I., Olsen, J., Jeune, B., Westergaard, J. G., Jacobsson, B., & Møller, B. R. (2006). Bacterial vaginosis in early pregnancy is associated with low birth weight and small for gestational age, but not with spontaneous preterm birth: a population-based study on Danish women. The Journal of Maternal-Fetal & Neonatal Medicine, 19(1), 1-7.
Yefet, E., Mirin, D., Massalha, M., Alter, A., & Nachum, Z. (2025). Screening for and treatment of bacterial vaginosis reduced preterm delivery in high-risk pregnant women: a systematic review and meta-analysis. Gynecologic and Obstetric Investigation, 22,1-10.
Watts, D.H., Krohn, M.A., Hillier, S.L., Eschenbach, D.A. (1990). Bacterial vaginosis as a risk factor for post-cesarean endometritis. Obstetrics & Gynecology, 75(1), 52-58.
Wu, J., Zhu, X., Tang, B., Wu, J., Wei, F., Wang, X., Li, L., Li, H., Zhang, Y., Wang, B., Wu, W., Hong, X. (2025). Effects of bacterial vaginosis treatment during pregnancy on maternal-fetal outcome: A systematic review and network meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 307, 175-183.