Liquid Chromatographic-Mass Spectrometric Analysis of Diclofenac Based Cu (II) Complex

Rukiye Aydın


Coordination compounds have an important place in the structure of living things. Because; coordination compounds have an important place in pharmacology, biological reactions such as electron transfers and reaction mechanisms of enzymes as co-factors of many enzymes. Copper, which has many functions in the human body, also has many benefits. Copper, which plays a role in the functioning of the central nervous system, is also effective in the formation of free energy in the body. Copper is also found in many enzymes and plays a role in protein synthesis in the body. Anemia, fatigue and weakness, weakness of the immune system, iron deficiency, loss of appetite and similar disorders are seen in iron deficiency. In our study, which has very few examples in the literature, bis {2- [2- (2,6-dichloroanilino) phenyl] acetato-ĸ2 O, O'} bis (1-vinly-1H-imidazole- ĸN3) copper (II) complex has been studied. In our study, it was investigated whether the axial ligands are replaced by the solvent when the synthesized diclofenac-based copper complex is dissolved in different solvents. When the diclofenac-based copper complex were dissolved in different solvents such as methanol, ethanol and acetonitrile, UV-VIS and FT-IR measurements were taken and their behaviour was examined. Mass confirmations of the new compounds formed by measurements using liquid chromatography mass spectrometry device were made. When the measurement results obtained using different measurement techniques are compared, it is seen that the results support each other.


Coordination compounds; Diclofenac based Cu (II) complex; Liquid chromatographic-mass spectrometric analysis

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