Hepatic and Renal Biochemical Profile of Male Wistar Rats Following Ingestion of Lacatomtom Drink
Hepatic and Renal Effects of Lacatomtom Drink in Male Rats
Keywords:
Psychoactive drink, liver, alanine transaminase, alkaline phosphatase, kidney, toxicityAbstract
There is rising concern about the physical health risks of unconventional psychoactive drugs. A notable substance in this regard, "Lacatomtom" (LTT), has gained popularity among Nigerian youths. This study evaluated hepatic and renal biochemical profiles of male Wistar rats following ingestion of LTT drink. 25 wistar rats were randomly placed into 5 groups of 5 rats. Group A (control): 0.5ml of distilled water, group B (Vehicle) 0.5ml Lacasera, and groups C, D, and E: 125, 500, and 1000mg/kg LTT drink orally for 30 days. Plasma sera were used to analyse biochemical parameters like alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), total protein, albumin, bilirubin, urea, creatinine, and blood electrolytes after treatments. Histopathological examination was carried out on liver and kidney sections. ALT levels were significantly higher in test group E (1000 mg/kg) than Normal control. LTT drink significantly (P>0.05) decreased ALP, total protein, and albumin levels in experimental group C compared to the control, but not in test groups D (500mg/kg) and E (1000mg/kg). Total and conjugated bilirubin, creatinine, urea, potassium (K+), sodium (Na+), and bicarbonate (HCO3-) levels in the blood did not differ significantly between the normal control and Lacatomtom-treated groups (C, D, and E). However, groups C and D had significantly lower chloride serum levels than the usual control. In conclusion, Lacatomtom may alter the homeostatic balance of the liver in a dose dependent manner. It is therefore recommended that public awareness campaigns be launched to educate adolescents on the potential health risk its consumption poses.
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