The role of erythrocyte indices in the differential diagnosis of microcytic anemia disorders
Erythrocyte indices in the differential diagnosis of microcytic anemia disorders
DOI:
https://doi.org/10.1071/ejmbs.v1i1.4Keywords:
Iron deficiency anemia, beta thalessemia minor, red cell indicesAbstract
The survival of the cells in the tissue depends on the delivery of sufficient oxygen. A small decrease in the erythocyte mass responsible for carrying blood to tissues causes hematological problems called anemia. Anemia cases are often considered as predictor of important diseases. In this respect, anemic diseases should be taken seriously and their causes should be investigated and evaluated. Iron deficiency anemia (IDA) and beta thalessemia minor (BTM) consititute the most of microcyter anemia. In this study, the role of erythrocyte indexes drived from hemogram parameters that can be made each center and easily accessible, in the diagnosis of IDA and BTM searched. Patients who apply to Kahramanmaras Sutcu Imam Hospital between January 2019 and March 2019 dates were included to research. Patients who have beta thalessemia minor and iron deficiency included in this study. 25 patients diagnosed IDA, 5 patients diagnosed BTM and 22 patients diagnosed beta thalessemia with iron deficiency anemia (DETMER) including in a total of 52 patients, were enrolled in this study. It has been calculated with the red blood cell indexes that are Mentzer Index (MI), Green & King Index (G&K), England & Fraser Index (E&F), RDW Index, Ricerca Index (RI), Srivastava Index (SI) ve Shine & Lal Index (S&L), in the differential diagnosis of patients that have iron deficiency anemia (IDA) and BTM. The red blood cell indexes’YI (Youden index) values were found as S&L (100%)>RI (84%) >E&F (%72) > RDW (64%) > G&K (64%) > RDWI (64%) > SI (56%) > MI (44%) >RBC (44%) in the differential diagnosis of IDA and BTM. YI (Youden Index) values of the red blood cell indexes were found as RDW (100%) > S&L (96.29%) RI (72.8%) > G&K (54.37%) >E&F (51.25%) > RDWI (50.6%) > SI (50.07%) > RBC (49.18%) > MI (45.18%) in the differential diagnosis of ‘‘IDA’’ diagnosed patient group and ‘‘BTM with DETMER’’ diagnosed patient group. S&L, RI and E&F has the highest index value in the differential diognosis of BTM and IDA. It is required to measure the level of ferritin, Hb electrophoresis, mutation analysis and HPLC analysis for the definitive diagnosis of patients who are considered iron deficiency and thalassemia minor as a result of the red blood cell indexes.
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